Recent Press
Pagliarini named HHMI Investigator
New Pagliarini Lab study published in Nature Metabolism
New Pagliarini Lab study published in Nature Metabolism
Via WUSTL
New Pagliarini Lab study published in Nature Metabolism
New Pagliarini Lab study published in Nature Metabolism
New Pagliarini Lab study published in Nature Metabolism
Via WUSTL
New Pagliarini Lab study published in Nature
New Pagliarini Lab study published in Nature
New Pagliarini Lab study published in Nature
Via WUSTL
All Press
New Pagliarini Lab study published in Nature
New Pagliarini Lab study published in Nature
View archive of articles about our lab
2025
January
- David McDonald joins the lab as the Administrative Coordinator.
- Maria Broering joins the lab as a rotation student.
- Our latest work with multiomics, led by Zak Baker, resulted in the discovery that TAG mobilization helps drive recovery from mitochondrial stress and is published in Nature Cell Biology.
- Lab alumna, Danielle Lohmann, is featured in the Morgridge Institute of Research "Rising Sparks" profile series.
2024
July
- Dave is named an HHMI Investigator.
- Juan Liu joins the lab as a mass spectrometry Lab Manager after completing her work with Jason Locasale at Duke.
- Xinyu (Sam) Zhu joins the lab as a postdoctoral fellow after completing his PhD with Paul Cobine at Auburn University.
June
- Eddie Rashan begins his postdoctoral fellowship in the Vander Heiden Lab.
May
- Abby Bartlett successfully defends her thesis, entitled "Biochemical investigations of uncharacterized, redox-active enzymes in lipid metabolism".
- Our study of NDUFAF6 function and variant pathogenicity using deep mutational scanning, let by Andrew Sung, is published in Nature Metabolism.
- Our work CoQ4 as a functional substitute for CoQ10, led by Laura Steenberge, is published in the Journal of Biological Chemistry.
March
- MSTP students meet their matches!
- Jon Tai — UCSF
- Laura Steenberge — University of Pittsburgh
- Andrew Sung — UT Southwestern
- Jimmy Mo joins our group as a new Molecular and Cellular Biology graduate student.
- Juan Cruz Herrero Martín joins our group as a postdoctoral fellow after completing his PhD with Laura Formentini in Madrid
2023
October
- Our latest work on the mitochondrial phosphatase Pptc7, led by Natalie Niemi, is published in Nature Communications.
- Our discovery of Hem25 as a mitochondrial isoprene transporter, let by Jon Tai, is published in Nature Cell Biology.
September
- Our new review of mitochondrial proteome research, let by Zak Baker and Patrick Forny, is published in Nature Reviews Molecular Cell Biology.
July
- Laura Steenberge's paper on CoQ analogs was posted to bioRxiv.
May
- Andrew Sung and Laura Steenberge successfully defend their Ph.D. theses (on the same day!)
March
- Jonathan Tai successfully defends his Ph.D. thesis
January
- Jonathan Schmitz successfully defends his Ph.D. thesis
- Our work describing the structure and function of Aim18 and Aim46, led by Jon Schmitz, was published in JBC.
- Vaibhav Deshmukh joins the group as a postdoctoral fellow
2022
November
- Our work describing the structure and function of Aim18 and Aim46, led by Jon Schmitz, was posted on bioRxiv.
- Fang accepts a position at Genentech.
September
- Our work describing the structure and functionality of a COQ7:COQ9 complex, led by Mateusz Manicki and Halil Aydin (Frost Lab), was accepted for publication at Molecular Cell.
- Mateusz accepts a position at AstraZeneca.
- Our work defining an inhibitor of COQ8A, led by Nate Murray, was accepted for publication at Nature Chemical Biology.
August
- Patrick Forny joins the group as a postdoctoral fellow.
July
- Our work defining an allosteric modulator of COQ8A, led by Nate Murray, was published in ACS Chemical Biology.
- Nate Murray successfully defends his Ph.D. thesis and accepts a position at Promega in Madison, WI.
May
- Our work defining functions for poorly characterized mitochondrial proteins, led by Jarred Rensvold and Evgenia Shiskova (Coon Lab), was published in Nature.
March
- Our work describing the small molecule modulation of the archetypal UbiB protein COQ8, led by Nate Murray, was posted on bioRxiv.
2021
November
- Our work describing the structure and functionality of a multimeric human COQ7:COQ9 complex, led by Mateusz Manick and by Halil Aydin from Adam Frost's group, was posted on bioRxiv.
- Our work describing the structure and function of PREPL, performed in collaboration with Prof. John Creemers' group at KU Leuven, was published in iScience.
October
- Dr. Sean Rogers joins our lab as a postdoctoral fellow after completing his PhD with Prof. Mike Henne at UT Southwestern.
August
- Our manuscript entitled, "UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae," led by Zack Kemmerer and Kyle Robinson, is published in Nature Communications.
April
- Our manuscript entitled, "Defining intermediates and redundancies in coenzyme Q precursor biosynthesis," led by Kyle Robinson, is published in the Journal of Biological Chemistry.
- Kyle Robinson successfully defends his PhD entitled, "Defining steps in coenzyme Q cellular distribution and precursor biosynthesis."
Janurary
- Dr. Zixiang Fang joins our lab as a mass spectrometry research specialist after completing his PhD with Saiful Chowdhury at UT Arlington.
2020
December
- Dr. Sanchari Datta joins the lab as a postdoctoral fellow after completing her PhD with Prof. Mike Henne at UT Southwestern.
- Zack Kemmerer successfully defends his PhD thesis entitled, "Understanding Atypical Kinases as Essential Factors for the Biosynthesis and Cellular Distribution of Coenzyme Q"
September
- Caroline Fecher joins the lab as a postdoc after completing her PhD with Thomas Misgeld in Munich.
July
- Our laboratory officially reopens in our new location at WashU!
- Chelsea White joins the lab as a Lab Manger.
- Lab alumna Natalie Niemi begins her independent career as an Assistant Professor of Biochemistry & Molecular Biophysics at WashU.
April
- CMB student Andrew Sung passes his preliminary examination to advance to candidacy.
- Our review describing the “systems biochemistry” approach to mitochondrial protein discovery, led by Andrew Sung, was published in Cell Metabolism
- Dr. Natalie Niemi has accepted a faculty position to start her own lab at Washington University in St. Louis in the department of Biochemistry and Molecular Biophysics. She will make her official move this summer.
March
- We’re moving! Dave has accepted a position as a BJC Investigator at Washington University School of Medicine in St. Louis starting May 1, 2020. The Pagliarini Lab is scheduled to move this summer.
- IPiB student Laura Steenberge passes her preliminary examination to advance to candidacy.
- Adam Jochem leaves the lab to begin as a Senior Research Specialist with Dr. Audrey Gasch at the University of Wisconsin-Madison.
2019
November
- IPiB student Abigail Bartlett passes her preliminary examination to advance to candidacy.
October
- Kyle Robinson receives the 2019 Pagliarini Lab Award. This award recognizes Kyle for his tenacity, rigor, and collegiality.
- Pagliarini lab is visited by U.S. Senator Tammy Baldwin for a discussion on the lab’s core focus areas and a tour. Learn more about her visit.
- Dr. Daniel Pensinger joins the lab as a Postdoctoral Fellow after completing his thesis work with Professor JD Sauer at the University of Wisconsin-Madison.
September
- Undergraduate Alana Caldwell joins the lab as a laboratory assistant.
August
- Jonathan Tai’s F31 predoctoral fellowship proposal entitled “A Yeast Genetics Approach to Identify and Characterize Mitochondrial Transporters in Coenzyme Q Biosynthesis” is funded by the National Institute on Aging.
- The Pagliarini lab celebrates its 10 year anniversary.
July
- Our manuscript describing an essential mitochondrial matrix protein phosphatase, led by Natalie Niemi, was published in Nature Communications.
- Dave is awarded the 2020 Earl and Thressa Stadtman Young Scholar Award from the American Society for Biochemistry and Molecular Biology.
- Dave’s R01 proposal entitled “Regulation of Mitochondrial Function by Orphan Protein Phosphatases” is funded by NIDDK.
- Lainy Von Bank leaves the lab to pursue her PhD at UW-Madison in the Cellular and Molecular Biology Program.
- Caroline Fecher, currently a graduate student in Dr. Thomas Misgeld lab at the Technical University of Munich in Munich, Germany, will join us as a postdoctoral fellow this winter/spring.
- Andrew Sung is awarded a spot on the Biology of Aging and Age-Related Disease T32.
June
- Rachel Guerra wins a 2019 Accelerator Prize from the United Mitochondrial Disease Foundation.
May
- Jaclyn Mabry leaves the lab to join Semba Biosciences in Madison, WI as a Research and Development Scientist.
- Laura Steenberge is awarded a spot on the Chemistry-Biology Interface Training Program (CBI) T32.
- Amy Lin leaves the lab to join Michael Sack’s lab at the National Health Lung Blood Institute, National Institute of Health as a Post baccalaureate Intramural Research Training Award fellow.
- Sheila Johnson leaves the lab to pursue her PhD at Harvard University in the Chemical Biology Program.
- Sheila Johnson receives her degree in Biochemistry from the University of Wisconsin-Madison
April
- Dave’s R35 proposal entitled “Systems-to-structure approaches for defining mitochondrial protein function” is funded by NIGMS.
- IPiB student Jonathan Tai passes his preliminary examination to advance to candidacy.
- Zachary Kemmerer is chosen to receive a Denis R.A. and Martha Washburn Wharton Fellowship through the Department of Biochemistry.
- Dave is awarded a 2019 H. I. Romnes Faculty Fellowship from the University of Wisconsin-Madison Office for the Vice Chancellor for Research and Graduate Education in recognition of his academic success.
- Keith Kamer receives a 2019 Hilldale Undergraduate/Faculty Research Fellowship.
- Lainy Von Bank is accepted into the Cellular and Molecular Biology PhD program at the University of Wisconsin-Madison
- Sheila Johnson is accepted into the Chemical Biology PhD program at Harvard University.
March
- Jonathan Stefely is matched with Massachusetts General Hospital - Clinical Pathology Specialty in Boston, MA.
February
- Molly McDevitt leaves the lab to join PPD in Middleton, WI as a Senior Scientist.
- Our manuscript describing the role of COQ9 in enabling CoQ biosynthesis, led by Danielle Lohman, and in collaboration with the Dal Peraro group in Lausanne, was published in Molecular Cell.
January
- IPiB student Molly McDevitt successfully defends her thesis entitled, “Systems biochemistry investigations into lipid metabolism and lipid-metabolizing enzymes”.