PUBLICATIONS
2025
- RTN4IP1 is essential for the final stages of mitochondrial complex I assembly and coenzyme Q biosynthesis
Olahova M, Guerra RM, Collier JJ, Heidler J, Thompson K, White CR, Castaneda-Tamez P, Cabrera-Orefice A, Lightowlers RN, Chrzanowska-Lightowlers ZMA, Wittig I, Pagliarini DJ and Taylor RW
EMBO Journal (Accepted) 2025 - ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism
Rashan EH, Bartlett AK, Khana DB, Zhang J, Jain R, Wade G, Abriata LA, Smith AJ, Baker ZN, Cook T, Caldwell A, Chevalier AR, Forny P, Pfleger BF, Peraro MD, Yuan P, Amador-Noguez D, Simcox JA, Pagliarini DJ.
Nature Structural & Molecular Biology 2025 - Identification of a new COQ4 spliceogenic variant causing severe primary coenzyme Q deficiency
Alcázar-Fabra M, Østergaard E, Fernández-Ayala DJM, Desbats MA, Morbidoni V, Tomás-Gallado L, García-Corzo L, Blanquer-Roselló MM, Bartlett AK, Sánchez-Cuesta A, Sena L, Cortés-Rodríguez A, Cascajo-Almenara MV, Pagliarini DJ, Trevisson E, Gronborg SW, and Brea-Calvo G
Molecular Genetics and Metabolism Reports 2025 - Triacylglycerol mobilization underpins mitochondrial stress recovery
Baker ZN, Zhu Y, Guerra RM, Smith AJ, Arra A, Serrano LR, Overmyer KA, Mukherji S, Craig EA, Coon JJ, Pagliarini DJ.
Nature Cell Biology 2025 - Multiomics reveals that triacylglycerol mobilization helps drive recovery from mitochondrial stress
Baker ZN and Pagliarini DJ
Nature Cell Biology 2025 - DFCP1 is a regulator of starvation-driven ATGL-mediated lipid droplet lipolysis
Ismail VA, Schuetz M, Baker ZN, Castillo-Badillo JA, Naismith TV, Pagliarini DJ, Kast DJ
Journal of Lipid Research 2025
Model figure for Rashan, et al
Nature Structural & Molecular Biology 2025
2024
- Fast and Deep Phosphoproteome Analysis with the Orbitrap Astral Mass Spectrometer
Lancaster NM, Sinitcyn P, Forny P, Peters-Clarke TM, Fecher C, Smith AJ, Shishkova E, Arrey TN, Pashkova A, Roninson ML, Arp N, Fan J, Hansen J, Galmozzi A, Serrano LR, Rojas J, Gasch AP, Westphall MS, Stewart H, Hock C, Damoc E, Pagliarini DJ, Zabrouskov V, and Coon JJ
Nature Communications 2024 - Systematic analysis of NDUFAF6 in complex I assembly and mitochondrial disease
Sung AY, Guerra RM, Steenberge LH, Alston CL, Murayama K, Okazaki Y, Shimura M, Prokisch H, Ghezzi D, Torraco A, Carrozzo R, Rötig A, Taylor RW, Keck JL, and Pagliarini DJ
Nature Metabolism 2024 - A systematic mutational framework for studying oxidative phosphorylation-related proteins
Sung AY and Pagliarini DJ
Nature Metabolism 2024 - Coenzyme Q4 is a functional substitute for coenzyme Q10 and can be targeted to the mitochondria
Steenberge LH, Rogers S, Sung AY, Fan J, and Pagliarini DJ
Journal of Biological Chemistry 2024
Model figure for Sung, et al.
Nature Metabolism 2024
2023
- TOMM40 and TOMM22 of the Translocase Outer Mitochondrial Membrane Complex rescue statin-impaired mitochondrial dynamics, morphology, and mitophagy in skeletal myotubes
Yang NV, Rogers S, Guerra R, Pagliarini DJ, Theusch, E, and Krauss RM
bioRxiv 2023 - COQ4 is required for the oxidative decarboxylation of the C1 carbon of Coenzyme Q in eukaryotic cells
Pelosi P, Morbiato L, Burgardt A, Tonello F, Bartlett AK, Guerra RM, Ferizhendi KK, Desbats MA, Rascalou B, Marchi M, Vazquez-Fonseca L, Agosto C, Zanotti G, Roger-Margueritat M, Alcázar-Fabra M, García-Corzo L, Sánchez-Cuesta A, Navas P, Brea-Calvo G, Trevisson E, Wendisch VF, Pagliarini DJ, Salviati L, and Pierrel F
Molecular Cell, 2024 - Reducing mitochondrial mysteries
Guerra RM and Pagliarini DJ
Nature Chemical Biology 2023 - Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy
Niemi NM†, Serrano L, Muehlbauer LK, Balnis C, Kozul K, Rashan EH, Shishkova E, Schueler K, Keller MP, Attie AD, Pagan J, Coon JJ, and Pagliarini DJ†
Nature Communications, 2023 - Hem25p is required for mitochondrial IPP transport in fungi
Tai JT, Guerra RM, Rogers SW, Fang Z, Muehlbauer KL, Shishkova E, Overmyer KA, Coon JJ, and Pagliarini DJ
Nature Cell Biology, 2023 - Mitochondrial proteome research: the road ahead
Baker ZN, Forny P, and Pagliarini DJ
Nature Reviews Molecular Cell Biology, 2023 - Aim18p and Aim46p are chalcone isomerase (CHI)-domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae
Schmitz JM, Wolters JF, Murray NH, Guerra RM, Saunders JM, Jochem J, Smith RW, Bingman CA, Hittinger CT and Pagliarini DJ
Journal of Biological Chemistry, 2023 - Coenzyme Q biochemistry and biosynthesis
Guerra RM and Pagliarini DJ
Trends in Biochemical Sciences, 2023
Model figure: Baker, Z.N., Forny, P. & Pagliarini, D.J.
Nature Reviews Molecular Cell Biology, 2023
2022
- Small Molecule Inhibition of the Archetypal UbiB protein COQ8
Murray NH, Asquith CR, Fang Z, Smith RW, Vasta JD, Zimprich CA, Corona CR, Robers MB, Bingman CA, and Pagliarini DJ
Nature Chemical Biology, 2022 - Structure and functionality of a multimeric human COQ7:COQ9 complex
Manicki M*, Aydin H*, Abriata LA, Overmyer KA, Guerra RM, Coon JJ, Dal Peraro M, Frost A† and Pagliarini DJ†
Molecular Cell, 2022 - Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases
Seim G, John SV, Arp NL, Fang Z, Pagliarini DJ, and Fan J
Nature Chemical Biology, 2022 - 2-propylphenol Allosterically Modulates COQ8A to Enhance ATPase Activity
Murray NH*, Lewis A*, Rincon Pabon JP, Gross ML, Henzler-Wildman K and Pagliarini DJ
ACS Chemical Biology, 2022 - Defining mitochondrial protein functions through deep multiomic profiling
Rensvold JW*, Shishkova E*, Miller IJ, Sverchkov Y, Cetinkaya A, Pyle A, Manicki M, Brademan DR, Alanay Y, Raiman J, Jochem J, Peters SR, Linke V, Hutchins PD, Overmyer KA, Salome AZ, Hebert AS, Balnis CV, Kwiecien NW, Rush MJ, Westphall MS, Craven M, Akarsu NA, Taylor RW, Coon JJ†, and Pagliarini DJ†
Nature, 2022
Cover submission for Murray et al., Nature Chem Bio 2022 (not selected)
Created by Galen Hicks
2021
- Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function
Rosier K, McDevitt MT, Smet J, Floyd BJ, Verschoore M, Marcaida MJ, Bingman CA, Lemmens I, Dal Peraro M, Tavernier J, Cravatt BF, Gounko NV, Vints K, Monnens Y, Bhalla K, Aerts L, Rashan EH, Vanlander A, Van Coster R, Régal L, Pagliarini DJ†, and Creemers JWM†
iScience, 2021 - UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae
Kemmerer ZA, Robinson KP, Schmitz JM, Manicki M, Paulson BR, Jochem A, Hutchins PD, Coon JJ, and Pagliarini DJ
Nature Communications, 2021 Aug 6;12(1):4769 - The extensive and functionally uncharacterized mitochondrial phosphoproteome
Niemi NM and Pagliarini DJ
Journal of Biological Chemistry, 2021 Jun 15:100880 - Loss of C2orf69 defines a fatal auto-inflammatory syndrome in Humans and Zebrafish that evokes a Glycogen storage-associated mitochondriopathy
Wong HH, Seet SH, Maier M, Gurel A, Traspas RM, Lee C , Shan Z, Talim B, Loh AYT, Chia CY, Teoh TS, Sng D, Rensvold R, Unal S, Shishkova E, Cepn E, Nathan FM, Sirota FL, Chao L, Yarali N, Simsek-Kiper PS, Tadahiro M, Ceylaner S, Arman-Bilir O, Mbarek H, Gumruk F, Efthymiou S, Çi̇men DU, i Georgiadou D, Sotiropoulou K, Houlden H, Paul F, Pehlivan D, Lainé C, Chai G, Ali NA, Choo SC, Keng SS, Boisson B, Yılmaz E, Xue S, Coon JJ, Ly TTN, Gilani N, Hasbini D, Kayserili H, Zaki M, Isfort RJ, Ordonez N, Tripolszki K, Bauer P, Rezaei N, Seyedpour S, Khotaei GT, Bascom CC, Maroofian R, Chaabouni M, AlSubhi A, Eyaid W, Işıkay S, Gleeson JS, Lupski JR, Casanova J-L, Pagliarini DJ, Akarsu NA, Maurer-Stroh S, Cetinkaya A, Bertoli-Avella A, Mathuru AS, Ho L, Bard F, Reversade B
American Journal of Human Genetics, 2021 May 21:S0002-9297(21)00187-7 - Defining intermediates and redundancies in coenzyme Q precursor biosynthesis
Robinson KP, Jochem A, Johnson SE, Reddy TR, Russell JD, Coon JJ, and Pagliarini DJ
Journal of Biological Chemistry, 2021 Apr 14;296:100643 - Multi-Omic Single-Shot Technology for Integrated Proteome and Lipidome Analysis
He Y, Rashan EH, Linke V, Shishkova E, Hebert AS, Jochem A, Westphall MS, Pagliarini DJ, Overmyer KA, and Coon JJ
Anal. Chem., 2021 Mar 9;93(9):4217-4222
Model figure for Kemmerer, et al
Nature Communications 2021
2020
- Quantitative shotgun proteome analysis by direct infusion
Meyer JG, Niemi NM, Pagliarini DJ, and Coon JJ
Nature Methods, 2020 Dec;17(12):1222-1228 - Argonaut: a Web Platform for Collaborative Multi-Omic Data Visualization and Exploration
Brademan DR, Miller IJ, Kwiecien KW, Pagliarini DJ, Westphall MS, Coon JJ, and Shishkova E
Patterns, 2020 Oct 9;1(7) - Label-free Method for Classification of T cell Activation
Walsh AJ, Mueller K, Jones I, Walsh CM, Piscopo N, Niemi NM, Pagliarini DJ, Saha K and Skala MC
Nature Biomedical Engineering, 2021 Jan;5(1):77-88 - Clinical, imaging, biomarker, and molecular delineation of COQ8A-ataxia: a multicenter study of 59 patients
Traschütz A, Schirinzi T, Laugwitz L, Murray NH, Reich S, Heinzmann A, Vasco G, Bertini E, Zanni G, Durr A, Magri S, Malandrini A, Taroni F, Baets J, de Jonghe P, de Ridder W, Bereau M, Demuth S, Ganos C, Basak N, Hanagasi H, Kurul SH, Bender B, Schöls L, Grashoff U, Klopstock T, Horvath R, van de Warrenburg B, Burglen L, Rougeot C, Ewenczyk C, Koenig M, Santorelli FM, Anheim M, Munhoz RP, Haack T, Distelmaier F, Pagliarini DJ, Puccio H, Synofzik M
Annals of Neurology, 2020 Aug;88(2):251-263 - Systems biochemistry approaches to defining mitochondrial protein function
Sung AY, Floyd BJ, and Pagliarini DJ
Cell Metabolism, 2020, 31 (4): 669-678 - Pathogenic biallelic mutations in NDUFAF8 cause Leigh syndrome with an isolated complex I deficiency
Alston CL*, Veling MT*, Heidler J, Taylor LC, Alaimo JT, Sung AY, He L, Hopton S, Broomfield A, Pavaine J, Pavaine J, Diaz J, Wolf P, McFarland R, Prokisch H, Wortmann SB, Bonnen PE, Wittig I, Pagliarini DJ†, and Taylor RW†
American Journal of Human Genetics, 2020 Jan 2;106(1):92-101. doi: 10.1016/j.ajhg.2019.12.001 - Mass spectrometry proteomics reveals a function for mammalian Calcoco1 in mTOR regulated selective autophagy
Stefely JA, Zhang Y, Freiberger EC, Kwiecien NW, Thomas HE, Davis AM, Lowry ND, Clark NA, Medvedovic M, Coon JJ, Pagliarini DJ, and Mercer CA
Autophagy, 2020 Dec;16(12):2219-2237
Cover submission (not selected) for Sung, Floyd, & Pagliarini 2020
Created by Matt Stefely
2019
- ADCK3/COQ8A: The choice target of the UbiB protein kinase-like family
Asquith CRM†, Murray NH, and Pagliarini DJ†
Nature Reviews Drug Discovery, 2019 Oct;18(11):815 - Pptc7 is an essential phosphatase that promotes mitochondrial metabolism by enabling protein import and processing
Niemi NM, Wilson GM, Overmyer KA, Vögtle FN, Lohman DC, Schueler KL, Attie AD, Meisinger C, Coon JJ, and Pagliarini DJ
Nature Communications, 2019 10: 3197 - Two-stage metabolic remodeling in macrophages in response to LPS and IFN-γ stimulation
Seim GL, Britt EC, John SV, Yeo F, Johnson A, Eisenstein R, Pagliarini DJ, and Fan J
Nature Metabolism, 2019 1:731–742 - Obesity-dependent Cdk1 Signaling Stimulates Mitochondrial Respiration at Complex I in Pancreatic β-cells
Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Pagliarini DJ, Denu JM, and Merrins MJ
Journal of Biological Chemistry, 2019 294(12):4656-4666 - Mitochondrial Coenzyme Q biosynthetic proteins cooperatively assemble in a substrate-dependent manner into domains spatially linked to ER-mitochondria contact site
Subramanian K, Jochem A, Lewis, S, Le Vasseur M, Paulson BR, Reddy TR, Russell JD, Coon JJ, Pagliarini DJ, and Nunnari J
Journal of Cell Biology, 2019 218(4):1353-1369 - An isoprene lipid binding protein promotes eukaryotic coenzyme Q biosynthesis
Lohman DC*, Aydin D*, Von Bank H, Smith R, Linke V, Weisenhorn EM, McDevitt MT, Hutchins PD, Wilkerson EM, Wancewicz B, Russell JD, Stefely MS, Beebe ET, Jochem A, Coon JJ, Bingman CA, Dal Peraro M†, and Pagliarini DJ†
Molecular Cell, 2019 73(4): 763-774
Cover submission (not selected) for Lohman et al. 2019
Created by Huston Design
2018
- Identification and Quantification of Murine Mitochondrial Proteoforms Using an Integrated Top-Down and Intact-Mass Strategy
Schaffer LV, Rensvold JW, Shortreed MR, Cesnik AJ, Jochem A, Scalf M, Frey BL, Pagliarini DJ, and Smith LM
Journal of Proteome Research 2018 17(10):3526-3536 - Systems analyses reveal physiological roles and genetic regulators of liver lipid species
Jha P*, McDevitt MT*, Gupta R*, Quiros PM, Williams EG, Gariani K, Sleiman MB, Diserens L, Jochem A, Ulbrich A, Coon JJ, Auwerx J†, and Pagliarini DJ†
Cell Systems, 2018 6(6):722-733 - Genetic regulation of plasma lipid species and their association with metabolic phenotypes
Jha P*, McDevitt MT*, Halilbasic E, Williams EG, Quiros PM, Gariani K, Sleiman MB, Ulbrich A, Coon JJ, Trauner M, Pagliarini DJ†, and Auwerx J†
Cell Systems, 2018 6(6):709-721 - A path to the powerhouse: systems-to-structure approaches for studying mitochondrial proteins
Pagliarini DJ
Protein Science, 2018 27(8):1518-1525 - DNA Polymerase θ Increases DNA Polymerase θ Increases Mutational Rates in Mitochondrial DNA
Wisnovsky S, Sack T, Pagliarini DJ, Laposa RR, and Kelley SO
ACS Chemical Biology, 2018 13(4):900-908 - Multi-Omics Reveal Specific Targets of the RNA-Binding Protein Puf3p and Its Orchestration of Mitochondrial Biogenesis
Lapointe CP*, Stefely JA*, Jochem A, Hutchins PD, Wilson GM, Kwiecien NW, Coon JJ, Wickens MP†, and Pagliarini DJ†
Cell Systems, 2018 6(1):125-135 - Conserved lipid and small molecule modulation of COQ8 reveals regulation of the ancient kinase-like UbiB family
Reidenbach AG, Kemmerer ZA, Aydin D, Jochem A, McDevitt MT, Hutchins PD, Stark JL, Stefely JA, Reddy T, Hebert AS, Wilkerson EM, JA, Johnson IE, Bingman CA, Markley JL, Coon JJ, Dal Peraro M, and Pagliarini DJ
Cell Chemical Biology, 2018 25(2):154-165
PREVIEW
Accepted cover for Reidenbach et al. 2018
Created by Amy Lin
2017
- Multi-omic mitoprotease profiling defines a role for Oct1p in coenzyme Q production
Veling MT, Reidenbach AG, Freiberger EC, Kwiecien NW, Hutchins PD, Drahnak MJ, Jochem A, Ulbrich A, Rush JPR, Russell JD, Coon JJ, and Pagliarini DJ
Molecular Cell, 2017 68(5):970-977 - Biochemistry of Mitochondrial Coenzyme Q Biosynthesis
Stefely JA and Pagliarini DJ
Trends in Biochemical Sciences, 2017 42(10):824-843 - Erythropoietin signaling regulates heme biosynthesis
Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Begonia H, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, Cantor AB, Maeda T, Phillips JD, Coon JJ, Pagliarini DJ, Dailey HA, and Paw BH
eLife, 2017 May 29;6. pii: e24767 - Integrative proteomics and biochemical analyses define Ptc6p as the Saccharomyces cerevisiae pyruvate dehydrogenase phosphatase
Guo X, Niemi NM, Coon JJ, Pagliarini DJ
Journal of Biological Chemistry, 2017 Jul 14;292(28):11751-11759 - Ptc7p Dephosphorylates Select Mitochondrial Proteins to Enhance Metabolic Function
Guo X*, Niemi NM*, Hutchins PD, Condon SG, Jochem A, Ulbrich A, Higbee AJ, Russell JD, Senes A, Coon JJ, Pagliarini DJ
Cell Reports, 2017 18(2):307-313
Cover submission (not selected) for Veling et al. 2017
Created by Mike Veling
2016
- Mitochondrial Protein Functions Elucidated by Multi-Omic Mass Spectrometry Profiling
Stefely JA*, Kwiecien NW*, Freiberger EC, Richards AL, Jochem A, Rush MJ, Ulbrich A, Robinson KP, Hutchins PD, Veiling MT, Guo X, Kemmerer ZA, Connors KJ, Trujillo EA, Sokol J, Marx H, Westphall MS, Hebert AS, Pagliarini DJ†, Coon JJ†
Nature Biotechnology, 2016 Sep 26 PMID: 27669165
PREVIEW - Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function
Floyd BJ*, Wilkerson EM*, Veling MT*, Minogue CE*, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JJ, Coon JJ,
Pagliarini DJ
Molecular Cell, 2016 Aug 18;63(4):621-32 - Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity
Stefely JA*, Licitra F*, Laredj L, Reidenbach AG, Kemmerer ZA, Grangeray A, Jaeg-Ehret T, Minogue CE, Ulbrich A, Hutchins PD, Wilkerson EM, Ruan Z, Aydin D, Hebert AS, Guo X, Freiberger EC, Reutenauer L, Jochem A, Chergova M, Johnson IE, Lohman DC, Rush MJ, Kwiecien NW, Singh PK, Schlagowski AI, Floyd BJ, Forsman U, Sindelar PJ, Westphall MS, Pierrel F, Zoll J, Dal Peraro M, Kannan N, Bingman CA, Coon JJ, Isope P, Puccio H†, Pagliarini DJ†
Molecular Cell, 2016 Aug 18;63(4):608-2. - Iron Deprivation Induces Transcriptional Regulation of Mitochondrial Biogenesis
Rensvold JW, Krautkramer KA, Dowell JA, Denu JM, Pagliarini DJ
Journal of Biological Chemistry, 2016 291(40):20827-20837 - Transomics: Mitochondrial Systems Analyses Get Supercomplex
Pagliarini DJ
Cell Metabolism, 2016 Jul 12;24(1):13-4 - Mitochondrial protein hyperacetylation in the failing heart
Overmyer KA, Evans CR, Qi NR, Minogue CE, Carson JJ, Chermside-Scabbo CJ, Koch LG, Britton SL, Pagliarini DJ, Coon JJ, Burant CF
JCI Insight, 2016 Feb;2(1)
Accepted cover for Floyd et al. 2016
Created by Red Spark Creative
2015
- A Single Kinase Generates the Majority of the Secreted Phosphoproteome
Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE
Cell, 2015 Jun 18;161(7):1619-32 - Maximal Oxidative Capacity during Exercise Is Associated with Skeletal Muscle Fuel Selection and Dynamic Changes in Mitochondrial Protein Acetylation
Overmyer KA, Evans CR, Qi NR, Minogue CV, Chermside-Scaboo CJ, Kock LG, Britton SL, Pagliarini DJ, Coon JJ and Burant CF
Cell Metabolism, 2015, 3;21(3):468-78 - Multiplexed Quantification for Data-independent Acquisition
Minogue CE, Hebert AS, Rensvold JW, Westphall MS, Pagliarini DJ and Coon JJ
Analytical Chemistry, 2015, 3;87(5):2570-5 - Mitochondrial ADCK3 Employs an Atypical Protein Kinase-like Fold to Enable Coenzyme Q Biosynthesis
Stefely JA*, Reidenbach AG*, Ulbrich A, Oruganty K, Floyd BJ, Jochem A, Saunders JM, Johnson IE, Minogue CE, Wrobel RL, Barber GE, Lee D, Li S, Kannan N, Coon JJ, Bingman CA and Pagliarini DJ
Molecular Cell, 2015, 57(1):83-94
Cover submission (not selected) for Stefely et al. 2015
Created by Jon Stefely
2014
- Mitochondrial COQ9 is a lipid binding protein that associates with COQ7 to enable coenzyme Q biosynthesis
Lohman DC*, Forouhar F*, Beebe ET, Stefeley MS, Minogue CE, Ulbrich A, Stefely JA, Sukumar S, Luna-Sánchez M, Lew S, Seetharaman J, Xiao R, Wang H, Wrobel RL, Everett JK, Mitchell JC, López LC, Coon JJ, Tong L† and Pagliarini DJ†
Proceedings of the National Academy of Sciences, 2014 111(44):E4697-705 - A Gly-zipper motif mediates homo-dimerization of the transmembrane domain of the mitochondrial kinase ADCK3
Khadria AS, Mueller BK, Stefely JA, Tan CH, Pagliarini DJ† and Senes A†
Journal of the American Chemical Society, 2014 136, 14068-77 - Intelligent data acquisition blends targeted and discovery methods
Bailey DJ, McDevitt MT, Westphall MS, Pagliarini DJ, Coon JJ
Journal of Proteome Research, 2014 Apr 4;13(4):2152-61 - Mitochondrial DNA variant in COX1 subunit significantly alters energy metabolism of geographically divergent wild isolates in Caenorhabditis elegans
Dingley SD, Polyak E, Ostrovsky J, Srinivasan S, Lee I, Rosenfeld A, Tsukikawa M, Xiao R, Selak M, Coon JJ, Hebert AS, Grimsrud PA, Pagliarini DJ, Gai X, Schurr TG, Huttemann M, Nakamaru-Ogiso E and Falk MJ
Journal of Molecular Biology, 2014 426(11):2199-216 - Neutron-encoded mass signatures for quantitative top-down proteomics
Rhoads TW, Rose CM, Bailey DJ, Molden RC, Still AJ, Riley NM, Merrill AE, Hebert AS, Westphall MS, Pagliarini DJ, Garcia BA and Coon JJ
Analytical Chemistry, 2014 Mar 4;86(5):2314-9
Cover submission (not selected) for Lohman et al. 2014
Created by Danielle Lohman
2013
- Hallmarks of a new era in mitochondrial biochemistry
Pagliarini DJ† and Rutter J†
Genes and Development 2013, 27(24): 2615-27 - Amine-reactive neutron-encoded labels for highly-plexed proteomic quantitation
Hebert AS, Merrill AE, Stefely JA, Westphall MS, Pagliarini DJ and Coon JJ
Molecular and Cellular Proteomics 2013, 12(11): 3360-9 - Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation
Still AJ*, Floyd BJ*, Hebert AS*, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, and Pagliarini DJ
Journal of Biological Chemistry 2013, 288(36): 26209-19 - Neutron-encoded mass signatures for multiplexed proteome quantification
Hebert AS, Merrill AE, Bailey DJ, Still AJ, Westphall MS, Strieter ER, Pagliarini DJ and Coon JJ
Nature Methods 2013, 10(4): 332-4 - Complementary RNA and protein profiling identifies iron as a key regulator of mitochondrial biogenesis
Rensvold JW, Ong SE, Jeevananthan A, Carr SA, Mootha VK and Pagliarini DJ
Cell Reports 2013, 3(1): 237-245 - Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome
Hebert AS*, Dittenhafer-Reed KE*, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM and Coon JJ
Molecular Cell 2013, 49: 186-199 - Inhibitors of bacterial tubulin target bacterial membranes in vivo
Foss MH, Eun YJ, Grove CI, Pauw DA, Sorto NA, Rensvold JW, Pagliarini DJ, Shaw JT and Weibel DB
MedChemCommun 2013: 4, 112-119
Accepted cover for Rensvold et al. 2013
Created by Jarred Rensvold
2012
- Solution NMR structure of yeast succinate dehydrogenase flavinylation factor Sdh5 reveals a putative Sdh1
binding site
Eletsky A, Jeong M, Kim H, Lee H, Xiao R, Pagliarini DJ, Prestegard JH, Winge DR, Montelione GT and Szyperski T
Biochemistry 2012, 51: 8475-7 - Automated gas-phase purification for accurate, multiplexed quantification on a stand-alone ion trap mass spectrometer
Vincent CE, Rensvold JW, Wenger CD, Peterson AC, Westphall MS, Pagliarini DJ and Coon JJ
Analytical Chemistry 2012, 85(4): 2079-86 - A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis
Grimsrud PA*, Carson JJ*, Hebert AS, Hubler SL, Niemi NM, Bailey DJ, Jochem A, Stapleton DS, Keller MP, Westphall MS, Yandell BS, Attie AD, Coon JJ and Pagliarini DJ
Cell Metabolism 2012, 16: 672-83 - Analysis of the acidic proteome with negative electron-transfer dissociation mass spectrometry
McAlister GC, Russell JD, Rumachik NG, Hebert AS, Syka JE, Geer LY, Westphall MS, Pagliarini DJ and Coon JJ
Analytical Chemistry 2012, 84(6): 2875-82
Cover submission (not selected) for Grimsrud et al. 2012
Created by AJ Bureta
Pre-2012
- Pharmacological targeting of the mitochondrial phosphatase PTPMT1
Doughty-Shenton DD, Joseph JD, Zhang J, Pagliarini DJ, Kim Y, Lu D, Dixon JE and Casey PJ
The Journal of Pharmacology and Experimental Therapeutics 2010, 332(2): 584-92 - Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans
Calvo SE*, Pagliarini DJ* and Mootha VK
Proceedings of the National Academy of Sciences USA 2009, 106: 7507-12 - Mutation of C20orf7 disrupts complex I assembly and causes lethal infantile mitochondrial disease
Sugiana C*, Pagliarini DJ*, McKenzie M, Kirby DM, Salemi R, Dahl HHM, Hutchison WM, Vascotto KA, Smith SM, Christodoulou J, Calvo SE, Mootha VK, Ryan MT and Thorburn DR
American Journal of Human Genetics 2008, 83(4): 468-78. - A mitochondrial protein compendium elucidates complex I disease biology
Pagliarini DJ*, Calvo SE*, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, and Mootha VK
Cell 2008, 134(1): 112-23.
PREVIEW - Dual specific phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane
Rardin MJ, Wiley SE, Murphy AN, Pagliarini DJ, and Dixon JE
Journal of Biological Chemistry 2008, 283(22): 15440-50. - Mitochondrial modulation: reversible phosphorylation takes center stage?
Pagliarini DJ and Dixon JE
Trends in Biochemical Sciences 2006, 31(1): 26-34 - Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic Beta cells
Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Casey PJ, and Dixon JE
Molecular Cell 2005, 19(2): 197-207
PREVIEW - Protein tyrosine phosphatases
Pagliarini, DJ *, Robinson, FL*, and Dixon, JE
Encyclopedia of Biochemistry 2004, 3: 536-42 - A PTEN-like phosphatase with a novel substrate specificity
Pagliarini DJ, Worby CA, and Dixon JE
Journal of Biological Chemistry 2004, 279(37): 38590-6 - A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi
Merlot S, Meili R, Pagliarini D, Maehama T, Dixon E, and Firtel RA
Journal of Biological Chemistry 2003, 278(41): 39866-73
Accepted cover for Pagliarini, Robinson, Dixon 2005
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