Welcome to the Pagliarini Lab at the Washington University School of Medicine in St. Louis

 We are an interdisciplinary team of scientists driven to understand the biochemical underpinnings of mitochondrial dysfunction in human diseases. Together, we integrate large-scale methodologies with traditional biochemistry to investigate the modulation, adaptation, and basic metabolic function of mitochondria.

**Read our new 2022 papers, including:**

 A Nature manuscript  on defining functions for mitochondrial proteins

A Nature Chemical Biology manuscript on drugging a mitochondrial pathway

A Molecular Cell manuscript on the structure and function of a CoQ complex