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      • CoQ Biosynthesis
      • Mitochondrial Regulation
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  • Home
  • Research
    • Overview
    • Systems Biochemistry
    • CoQ Biosynthesis
    • Mitochondrial Regulation
  • Publications
    • Featured
    • All by year
  • News
  • Meet Our Team
    • Dave Pagliarini
    • Current Lab
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Featured Publications

Select recent research articles

  • ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism  
    Rashan EH, Bartlett AK, Khana DB, Zhang J, Jain R, Smith AJ, Baker ZN, Cook T, Caldwell A, Chevalier AR, Pfleger BF, Yuan P, Amador-Noguez D, Simcox JA, and Pagliarini DJ
    Nature Molecular & Structural Biology, 2025
  • Triacylglycerol mobilization underpins mitochondrial stress recovery   
    Baker ZN, Zhu Y, Guerra RM, Smith AJ, Arra A, Serrano LR, Overmyer KA, Mukherji S, Craig EA, Coon JJ, Pagliarini DJ.  
    Nature Cell Biology, 2025
  • Systematic analysis of NDUFAF6 in complex I assembly and mitochondrial disease
    Sung AY, Guerra RM, Steenberge LH, Alston CL, Murayama K, Okazaki Y, Shimura M, Prokisch H, Ghezzi D, Torraco A, Carrozzo R, Rötig A, Taylor RW, Keck JL, and Pagliarini DJ  
    Nature Metabolism, 2024
  • Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy
    Niemi NM†, Serrano L, Muehlbauer LK, Balnis C, Kozul K, Rashan EH, Shishkova E, Schueler K, Keller MP, Attie AD, Pagan J, Coon JJ, and Pagliarini DJ†
    Nature Communications, 2023
  • Hem25p is required for mitochondrial IPP transport in fungi
    Tai JT, Guerra RM, Rogers SW, Fang Z, Muehlbauer KL, Shishkova E, Overmyer KA, Coon JJ, and Pagliarini DJ
    Nature Cell Biology, 2023
  • Small Molecule Inhibition of the Archetypal UbiB protein COQ8
    Murray NH, Asquith CR, Fang Z, Smith RW, Vasta JD, Zimprich CA, Corona CR, Robers MB, Bingman CA, and Pagliarini DJ
    Nature Chemical Biology, 2022
  • Structure and functionality of a multimeric human COQ7:COQ9 complex
    Manicki M*, Aydin H*, Abriata LA, Overmyer KA, Guerra RM, Coon JJ, Dal Peraro M, Frost A† and Pagliarini DJ†
    Molecular Cell, 2022
  • Defining mitochondrial protein functions through deep multiomic profiling
    Rensvold JW*, Shishkova E*, Miller IJ, Sverchkov Y, Cetinkaya A, Pyle A, Manicki M, Brademan DR, Alanay Y, Raiman J, Jochem J, Peters SR, Linke V, Hutchins PD, Overmyer KA, Salome AZ, Hebert AS, Balnis CV, Kwiecien NW, Rush MJ, Westphall MS, Craven M, Akarsu NA, Taylor RW, Coon JJ†, and Pagliarini DJ†
    Nature, 2022  
  • UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae
    Kemmerer ZA, Robinson KP, Schmitz JM, Manicki M, Paulson BR, Jochem A, Hutchins PD, Coon JJ, and Pagliarini DJ
    Nature Communications, 2021 


Accepted cover for Floyd et al. 2016

Created by Red Spark Creative

Select recent reviews

  • Mitochondrial proteome research: the road ahead
    Baker ZN, Forny P, and Pagliarini DJ
    Nature Reviews Molecular Cell Biology, 2023
  • The extensive and functionally uncharacterized mitochondrial phosphoproteome
    Niemi NM and Pagliarini DJ
    Journal of Biological Chemistry, 2021 Jun 15:100880
  • Systems biochemistry approaches to defining mitochondrial protein function
    Sung AY, Floyd BJ, and Pagliarini DJ
    Cell Metabolism, 2020, 31 (4): 669-678


Accepted cover for Rensvold et al. 2013

Created by Jarred Rensvold

2025 Pagliarini Lab

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